Which two substances are most useful for determining a patients glomerular filtration rate

  1. Smith HW (1951) The kidney. Structure and function in health and disease. Oxford University Press, New York, pp 492–519

    Google Scholar 

  2. McCance RA, Widdowson EM (1952) The correct physiological basis on which to compare infant and adult renal function. Lancet 2:860–862

    CAS  PubMed  Google Scholar 

  3. Peters AM, Gordon I, Sixt R (1994) Normalization of glomerular filtration rate in children: body surface area, body weight or extracellular fluid volume? J Nucl Med 35:438–444

    CAS  PubMed  Google Scholar 

  4. Kanwar YS, Venkatachalam MA (1992) Ultrastructure of glomerulus and juxtaglomerular apparatus, chap. 1. In: Windhager EE (ed) Handbook of physiology, section 8: Physiology vol 1. Oxford University Press, NY, pp 3–40

    Google Scholar 

  5. Hoy WE, Douglas-Denton RN, Hughson MD, Cass A, Johnson K, Bertram JF (2003) A stereological study of glomerular number and volume: preliminary findings in a multiracial study of kidneys at autopsy. Kidney Int Suppl 83:S31–S37

    Google Scholar 

  6. Hughson MD, Douglas-Denton R, Bertram JF, Hoy WE (2006) Hypertension, glomerular number, and birth weight in African Americans and white subjects in the southeastern United States. Kidney Int 69:671–678

    CAS  PubMed  Google Scholar 

  7. Rose BD, Post TW (2001) Renal circulation and glomerular filtration rate, chap. 2. In: Wonsiewicz M, McCullough K, Davis K (eds) Clinical physiology of acid–base and electrolyte disorders, 5th edn. McGraw-Hill, NY, pp 21–70

    Google Scholar 

  8. Kanwar YS (1984) Biophysiology of glomerular filtration and proteinuria. Lab Invest 51:7–21

    CAS  PubMed  Google Scholar 

  9. Addis T, Myers BA, Oliver J (1924) The regulation of renal activity. IX. The effect of unilateral nephrectomy on the function and structure of the remaining kidney. Arch Intern Med 34:243–257

    CAS  Google Scholar 

  10. Dalton RN, Haycock GB (1999) Laboratory investigation, chap. 20. In: Barratt TM, Avner ED, Harmon WE (eds) Pediatric nephrology, 4th edn. Lippincott Williams & Wilkins, Baltimore, pp 343–364

    Google Scholar 

  11. Arant BS Jr, Edelmann CM Jr, Spitzer A (1972) The congruence of creatinine and inulin clearances in children: Use of the Technicon autoanalyzer. J Pediatr 81:559–561

    PubMed  Google Scholar 

  12. Cole BR, Giangiacomo J, Ingelfinger JR, Robson AM (1972) Measurement of renal function without urine collection. N Engl J Med 287:1109–1114

    CAS  PubMed  Google Scholar 

  13. U.S. Renal Data System, USRDS 2002 Annual data report (2002) Atlas of end-stage renal disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

  14. Talbot NB (1938) Measurement of obesity by the creatinine coefficient. Am J Dis Child 55:42–50

    CAS  Google Scholar 

  15. Doolan PD, Alpen EL, Theil GB (1962) A clinical appraisal of the plasma concentration and endogenous clearance of creatinine. Am J Med 32:65–79

    CAS  PubMed  Google Scholar 

  16. Schutte JE, Longhurst JC, Gaffney FA, Bastian BC, Blomqvist CG (1981) Total plasma creatinine: an accurate measure of total striated muscle mass. J Appl Physiol 51:762–766

    CAS  PubMed  Google Scholar 

  17. Schwartz GJ, Gauthier B (1985) A simple estimate of glomerular filtration rate in adolescent boys. J Pediatr 106:522–526

    CAS  PubMed  Google Scholar 

  18. Schwartz GJ, Feld LG, Langford DJ (1984) A simple estimate of glomerular filtration rate in full-term infants during the first year of life. J Pediatr 104:849–854

    CAS  PubMed  Google Scholar 

  19. Hellerstein S, Berenbom M, Erwin P, Wilson N, DiMaggio S (2006) Timed-urine collections for renal clearance studies. Pediatr Nephrol 21:96–101

    PubMed  Google Scholar 

  20. National Kidney Foundation. K/DOQI Clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification, part 5. Evaluation of laboratory measurements for clinical assessment of kidney disease guideline 4. Estimation of GFR. Website. 2002 6-23-2006, electronic citation

  21. Greenblatt DJ, Ransil BJ, Harmatz JS, Smith TW, Duhme DW, Koch-Weser J (1976) Variability of 24-hour urinary creatinine excretion by normal subjects. J Clin Pharmacol 16:321–328

    CAS  PubMed  Google Scholar 

  22. Richardson JA, Philbin PE (1971) The one-hour creatinine clearance rate in healthy men. JAMA 216:987–990

    CAS  PubMed  Google Scholar 

  23. van Acker BAC, Koomen GCM, Koopman MG, de Waart DR, Arisz L (1992) Creatinine clearance during cimetidine administration for measurement of glomerular filtration rate. Lancet 340:1326–1329

    PubMed  Google Scholar 

  24. Hellerstein S, Berenbom M, Alon US, Warady BA (1998) Creatinine clearance following cimetidine for estimation of glomerular filtration rate. Pediatr Nephrol 12:49–54

    CAS  PubMed  Google Scholar 

  25. Hellerstein S, Erwin P, Warady BA (2003) The cimetidine protocol: a convenient, accurate, and inexpensive way to measure glomerular filtration rate. Pediatr Nephrol 18:71–72

    PubMed  Google Scholar 

  26. Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259–263

    CAS  PubMed  Google Scholar 

  27. Schwartz GJ, Brion LP, Spitzer A (1987) The use of plasma creatinine concentration for estimating glomerular filtration rate in infants, children, and adolescents. Pediatr Clin North Am 34:571–590

    CAS  PubMed  Google Scholar 

  28. Zappitelli M, Parvex P, Joseph L, Paradis G, Grey V, Lau S, Bell L (2006) Derivation and validation of cystatin C-based prediction equations for GFR in children. Am J Kidney Dis 48:221–230

    CAS  PubMed  Google Scholar 

  29. Filler G, Priem F, Lepage N, Sinha P, Vollmer I, Clark H, Keely E, Matzinger M, Akbari A, Altaus H, Jung K (2002) β-Trace protein, cystatin C, β2-microglobulin, and creatinine compared for detecting impaired glomerular filtration rates in children. Clin Chem 48:729–736

    CAS  PubMed  Google Scholar 

  30. Schwartz GJ, Furth S, Cole S, Warady B, Munoz A (2006) Glomerular filtration rate via plasma iohexol disappearance: Pilot study for chronic kidney disease in children. Kidney Int 69:2070–2077

    CAS  PubMed  Google Scholar 

  31. Counahan R, Chantler C, Ghazali S, Kirkwood B, Rose F, Barratt TM (1976) Estimation of glomerular filtration rate from plasma creatinine concentration in children. Arch Dis Child 51:875–878

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Fong J, Johnston S, Valentino T, Notterman D (1995) Length/serum creatinine ratio does not predict measured creatinine clearance in critically ill children. Clin Pharmacol Ther 58:192–197

    CAS  PubMed  Google Scholar 

  33. Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31–41

    CAS  PubMed  Google Scholar 

  34. Pierrat A, Gravier E, Saunders C, Caira MV, Ait-Djafer Z, Legras B, Mallie JP (2003) Predicting GFR in children and adults: a comparison of the Cockcroft-Gault, Schwartz, and Modification of Diet in Renal Disease formulas. Kidney Int 64:1425–1436

    PubMed  Google Scholar 

  35. Finney H, Newman DJ, Thakkar H, Fell JM, Price CP (2000) Reference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 82:71–75

    CAS  PubMed  PubMed Central  Google Scholar 

  36. Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Brodehl J (1998) Reference values for cystatin C serum concentrations in children. Pediatr Nephrol 12:125–129

    PubMed  Google Scholar 

  37. Grubb A (1992) Diagnostic value of analysis of cystatin C and protein HC in biological fluids. Clin Nephrol 38:S20–S27

    CAS  PubMed  Google Scholar 

  38. Tenstad O, Roald AB, Grubb A, Aukland K (1996) Renal handling of radiolabelled human cystatin C in the rat. Scand J Clin Lab Invest 56:409–414

    CAS  PubMed  Google Scholar 

  39. Keevil BG, Kilpatrick ES, Nichols SP, Maylor PW (1998) Biological variation of cystatin C: implications for the assessment of glomerular filtration rate. Clin Chem 44:1535–1539

    CAS  PubMed  Google Scholar 

  40. Dworkin LD (2001) Serum cystatin C as a marker of glomerular filtration rate. Curr Opin Nephrol Hypertens 10:551–553

    CAS  PubMed  Google Scholar 

  41. Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, Vera M, Piera C, Darnell A (2000) Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis 36:29–34

    CAS  PubMed  Google Scholar 

  42. Christensson A, Ekberg J, Grubb A, Ekberg H, Lindstrom V, Lilja H (2003) Serum cystatin C is a more sensitive and more accurate marker of glomerular filtration rate than enzymatic measurements of creatinine in renal transplantation. Nephron Physiol 94:19–27

    Google Scholar 

  43. Stickle D, Cole B, Hock K, Hruska KA, Scott MG (1998) Correlation of plasma concentrations of cystatin C and creatinine to inulin clearance in a pediatric population. Clin Chem 44:1334–1338

    CAS  PubMed  Google Scholar 

  44. Filler G, Priem F, Vollmer I, Gellermann J, Jung K (1999) Diagnostic sensitivity of serum cystatin for impaired glomerular filtration rate. Pediatr Nephrol 13:501–505

    CAS  PubMed  Google Scholar 

  45. Ylinen EA, Ala-Houhala M, Harmoinen APT, Knip M (1999) Cystatin C as a marker for glomerular filtration rate in pediatric patients. Pediatr Nephrol 13:506–509

    CAS  PubMed  Google Scholar 

  46. Laterza OF, Price CP, Scott MG (2002) Cystatin C: an improved estimator of glomerular filtration rate? Clin Chem 48:699–707

    CAS  PubMed  Google Scholar 

  47. Filler G, Lepage N (2003) Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 18:981–985

    PubMed  Google Scholar 

  48. Martini S, Prévot A, Mosig D, Werner D, van Melle G, Guignard JP (2003) Glomerular filtration rate: measure creatinine and height rather than cystatin C! Acta Paediatr 92:1052–1057

    CAS  PubMed  Google Scholar 

  49. Bökenkamp A, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J (1999) Cystatin C serum concentrations underestimate glomerular filtration rate in renal transplant recipients. Clin Chem 45:1866–1868

    PubMed  Google Scholar 

  50. Knight EL, Verhave JC, Spiegelman D, Hillege HL, de Zeeuw D, Curhan GC, de Jong PE (2004) Factors influencing serum cystatin C levels other than renal function and the impact on renal function measurement. Kidney Int 65:1416–1421

    CAS  PubMed  Google Scholar 

  51. Tkaczyk M, Nowicki M, Lukamowicz J (2004) Increased cystatin C concentration in urine of nephrotic children. Pediatr Nephrol 19:1278–1280

    PubMed  Google Scholar 

  52. Uchida K, Gotoh A (2002) Measurement of cystatin-C and creatinine in urine. Clin Chim Acta 323:121–128

    CAS  PubMed  Google Scholar 

  53. Sapirstein LA, Vidt DG, Mandel MJ, Hanusek G (1955) Volumes of distribution and clearances of intravenously injected creatinine in the dog. Am J Physiol 181:330–336

    CAS  PubMed  Google Scholar 

  54. Brochner-Mortensen J (1972) A simple method for the determination of glomerular filtration rate. Scand J Clin Lab Invest 30:271–274

    CAS  PubMed  Google Scholar 

  55. Brochner-Mortensen J, Haahr J, Christoffersen J (1974) A simple method for accurate assessment of the glomerular filtration rate in children. Scand J Clin Lab Invest 33:139–143

    Google Scholar 

  56. Piepsz A, Denis R, Ham HR, Dobbeleir A, Schulman C, Erbsmann F (1978) A simple method for measuring separate glomerular filtration rate using a single injection of 99mTc-DTPA and the scintillation camera. J Pediatr 93:769–774

    CAS  PubMed  Google Scholar 

  57. LaFrance ND, Drew HH, Walser M (1988) Radioisotopic measurement of glomerular filtration rate in severe chronic renal failure. J Nucl Med 29:1927–1930

    CAS  PubMed  Google Scholar 

  58. Rehling M, Moller ML, Thamdrup B, Lund JO, Trap-Jensen J (1984) Simultaneous measurement of renal clearance and plasma clearance of 99mTc-labelled diethylenetriaminepenta-acetate, 51Cr-labelled ethylenediaminetetra-acetate and inulin in man. Clin Sci 66:613–619

    CAS  Google Scholar 

  59. Carlsen JE, Moller ML, Lund JO, Trap-Jensen J (1980) Comparison of four commercial Tc-99m(Sn)DTPA preparations used for the measurement of glomerular filtration rate: concise communication. J Nucl Med 21:126–129

    CAS  PubMed  Google Scholar 

  60. Odlind B, Hällgren R, Sohtell M, Lindström B (1985) Is 125I iothalamate an ideal marker for glomerular filtration? Kidney Int 27:9–16

    CAS  PubMed  Google Scholar 

  61. Perrone RD, Steinman TI, Beck GJ, Skibinski CI, Royal HD, Lawlor M, Hunsicker LG (1990) Utility of radioisotopic filtration markers in chronic renal insufficiency: simultaneous comparison of 125I-iothalamate, 169Yb-DTPA, 99mTc-DTPA, and inulin. Am J Kidney Dis 16:224–235

    CAS  PubMed  Google Scholar 

  62. Guignard J-P, Santos F (2004) Laboratory investigations, chap. 21. In: Avner ED, Harmon WE, Niaudet P (eds) Pediatric nephrology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 399–424

    Google Scholar 

  63. Back SE, Krutzen E, Nilsson-Ehle P (1988) Contrast media as markers for glomerular filtration: a pharmacokinetic comparison of four agents. Scand J Clin Lab Invest 48:247–253

    CAS  PubMed  Google Scholar 

  64. Krutzen E, Back SE, Nilsson-Ehle I, Nilsson-Ehle P (1984) Plasma clearance of a new contrast agent, iohexol: a method for the assessment of glomerular filtration rate. J Lab Clin Med 104:955–961

    CAS  PubMed  Google Scholar 

  65. Olsson B, Aulie A, Sveen K, Andrew E (1983) Human pharmacokinetics of iohexol: a new nonionic contrast medium. Invest Radiol 18:177–182

    CAS  PubMed  Google Scholar 

  66. Nilsson-Ehle P, Grubb A (1994) New markers for the determination of GFR: Iohexol clearance and cystatin C serum concentration. Kidney Int 46:S-17–S-19

    Google Scholar 

  67. Krutzen E, Back SE, Nilsson-Ehle P (1990) Determination of glomerular filtration rate using iohexol clearance and capillary sampling. Scand J Clin Lab Invest 50:279–283

    CAS  PubMed  Google Scholar 

  68. Niculescu-Duvaz I, D’Mello L, Maan Z, Barron JL, Newman DJ, Dockrell ME, Kwan JT (2006) Development of an outpatient finger-prick glomerular filtration rate procedure suitable for epidemiological studies. Kidney Int 69:1272–1275

    CAS  PubMed  Google Scholar 

  69. Gaspari F, Perico N, Ruggenenti P, Mosconi L, Amuchastegui CS, Guerini E, Daina E, Remuzzi G (1995) Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol 6:257–263

    CAS  PubMed  Google Scholar 

  70. Brown SCW, O’Reilly PH (1991) Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard. J Urol 146:675–679

    CAS  PubMed  Google Scholar 

  71. Erley CM, Bader BD, Berger ED, Vochazer A, Jorzik JJ, Dietz K, Risler T (2001) Plasma clearance of iodine contrast media as a measure of glomerular filtration rate in critically ill patients. Crit Care Med 29:1544–1550

    CAS  PubMed  Google Scholar 

  72. Rahn KH, Heidenreich S, Bruckner D (1999) How to assess glomerular function and damage in humans. J Hypertens 17:309–317

    CAS  PubMed  Google Scholar 

  73. Brändström E, Grzegorczyk A, Jacobsson L, Friberg P, Lindahl A, Aurell M (1998) GFR measurement with iohexol and 51Cr-EDTA. A comparison of the two favoured GFR markers in Europe. Nephrol Dial Transplant 13:1176–1182

    PubMed  Google Scholar 

  74. Chantler C, Barratt TM (1972) Estimation of glomerular filtration rate from plasma clearance of 51-chromium edetic acid. Arch Dis Child 47:613–617

    CAS  PubMed  PubMed Central  Google Scholar 

  75. Fleming JS, Zivanovic MA, Blake GM, Burniston M, Cosgriff PS, British Nuclear Medicine Society (2004) Guidelines for the measurement of glomerular filtration rate using plasma sampling. Nucl Med Commun 25:759–769

    PubMed  Google Scholar 

  76. Brion LP, Fleischman AR, McCarton C, Schwartz GJ (1986) A simple estimate of glomerular filtration rate in low birth weight infants during the first year of life: noninvasive assessment of body composition and growth. J Pediatr 109:698–707

    CAS  PubMed  Google Scholar 

  77. Guignard JP, Torrado A, Da Cunha O, Gautier E (1975) Glomerular filtration rate in the first three weeks of life. J Pediatr 87:268–272

    CAS  PubMed  Google Scholar 

  78. Barnett HL, McNamara H, Shultz S, Tompsett R (1949) Renal clearances of sodium penicillin G, procaine penicillin G, and inulin in infants and children. Pediatrics 3:418–422

    CAS  PubMed  Google Scholar 

  79. Barnett HL, Hare WK, McNamara H, Hare RS (1948) Influence of postnatal age on kidney function of premature infants. Proc Soc Exp Biol Med 69:55–57

    CAS  PubMed  Google Scholar 

  80. Richmond JB, Kravitz H, Segar W, Waisman HA (1951) Renal clearance of endogenous phosphate in infants and children. Proc Soc Exp Biol Med 77:83–87

    CAS  PubMed  Google Scholar 

  81. Broberger U (1973) Determination of glomerular filtration rate in the newborn. Comparison between results obtained by the single injection technique without collection of urine and the standard clearance technique. Acta Paediatr Scand 62:625–629

    CAS  PubMed  Google Scholar 

  82. McCrory WW, Forman CW, McNamara H, Barnett HL (1952) Renal excretion of inorganic phosphate in newborn infants. J Clin Invest 31:357–366

    CAS  PubMed  PubMed Central  Google Scholar 

  83. Brodehl J, Gellissen K, Weber HP (1982) Postnatal development of tubular phosphate reabsorption. Clin Nephrol 17:163–171

    CAS  PubMed  Google Scholar 

  84. Gibb DM, Dalton NR, Barratt MT (1989) Measurement of glomerular filtration rate in children with insulin-dependent diabetes mellitus. Clin Chim Acta 182:131–139

    CAS  PubMed  Google Scholar 


Page 2

From: Glomerular filtration rate measurement and estimation in chronic kidney disease

Age (gender) Mean GFR ± SD (ml/min per 1.73 m2) Reference
Pre-term babies
 1–3 days 14.0 ± 5 [76]
 1–7 days 18.7 ± 5.5 [77]
 4–8 days 44.3 ± 9.3 [78]
 3–13 days 47.8 ± 10.7 [79]
 8–14 days 35.4 ± 13.4 [77]
 1.5–4 months 67.4 ± 16.6 [79]
Term babies
 1–3 days 20.8 ± 5.0 [77]
 3–4 days 39.0 ± 15.1 [80]
 4–14 days 36.8 ± 7.2 [81]
 6–14 days 54.6 ± 7.6 [82]
 15–19 days 46.9 ± 12.5 [77]
 1–3 months 85.3 ± 35.1 [80]
 0–3 months 60.4 ± 17.4 [83]
 4–6 months 87.4 ± 22.3 [83]
 7–12 months 96.2 ± 12.2 [83]
 1–2 years 105.2 ± 17.3 [83]
Children
 3–4 years 111.2 ± 18.5 [83]
 5–6 years 114.1 ± 18.6 [83]
 7–8 years 111.3 ± 18.3 [83]
 9–10 years 110.0 ± 21.6 [83]
 11–12 years 116.4 ± 18.9 [83]
 13–15 years 117.2 ± 16.1 [83]
 2.7–11.6 years 127.1 ± 13.5 [78]
 9–12 years 116.6 ± 18.1 [80]
Young adults
 16.2–34 years 112 ± 13 [84]