Would you describe metabolic pathways as inherently wasteful or inherently economical and why provide examples in your reasoning?

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The frequency of publications on the Warburg Effect from the 1920s-2010s

The Warburg Effect has been studied extensively since the 1920s with a surge in the number of publications from the 2000s to today. Many of the proposed functions of the Warburg Effect have also gained vastly renewed interest. Although energy (ATP), biosynthesis, and ROS have been intricately studied in the context of the Warburg Effect, acidification and acetylation have only recently gained attention.

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