What structural joint changes are common in older people

From about age 30, the density of bones begins to diminish in men and women. This loss of bone density accelerates in women after menopause Menopause Menopause is the permanent end of menstrual periods and thus of fertility. For up to several years before and just after menopause, estrogen levels fluctuate widely, periods become irregular... read more

What structural joint changes are common in older people
. As a result, bones become more fragile and are more likely to break (see Osteoporosis Osteoporosis Osteoporosis is a condition in which a decrease in the density of bones weakens the bones, making breaks (fractures) likely. Aging, estrogen deficiency, low vitamin D or calcium intake, and... read more
What structural joint changes are common in older people
), especially in old age.

As people age, their joints are affected by changes in cartilage and in connective tissue. The cartilage inside a joint becomes thinner, and components of the cartilage (the proteoglycans—substances that help provide the cartilage's resilience) become altered, which may make the joint less resilient and more susceptible to damage. Thus, in some people, the surfaces of the joint do not slide as well over each other as they used to. This process may lead to osteoarthritis Osteoarthritis (OA) Osteoarthritis is a chronic disorder that causes damage to the cartilage and surrounding tissues and is characterized by pain, stiffness, and loss of function. Arthritis due to damage of joint... read more

What structural joint changes are common in older people
.

Additionally, joints become stiffer because the connective tissue within ligaments and tendons becomes more rigid and brittle. This change also limits the range of motion of joints.

Loss of muscle (sarcopenia) is a process that starts around age 30 and progresses throughout life. In this process, the amount of muscle tissue and the number and size of muscle fibers gradually decrease. The result of sarcopenia is a gradual loss of muscle mass and muscle strength. This mild loss of muscle strength places increased stress on certain joints (such as the knees) and may predispose a person to arthritis or falling. Fortunately, the loss in muscle mass and strength can partially be overcome or at least significantly delayed by a program of regular exercise.

The types of muscle fibers are affected by aging as well. The numbers of muscle fibers that contract faster decrease much more than the numbers of muscle fibers that contract slower. Thus, muscles are not able to contract as quickly in old age.

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Page 2

Aging Changes in Joint Tissues and the Contribution of Aging to the Development of OA.

Aging ChangeContribution to OA
Accumulation of cells exhibiting the senescent secretory phenotypeIncreased cytokine and MMP production stimulates matrix degradation
Oxidative stress/damageIncreased susceptibility to cell death and reduced matrix synthesis
Decreased levels of growth factors and decreased growth factor responsivenessReduced matrix synthesis and repair
Increased AGE formationBrittle tissue with increased fatigue failure
Reduced aggrecan size and cartilage hydration and increased collagen cleavageReduced resiliency and tensile strength
Increased matrix calcificationAltered mechanical properties and potential activation of inflammatory signaling