What is the difference between healing by primary intention and healing by secondary intention?

In wound healing, primary wound healing (sanatio per primam intentionem) and secondary wound healing (sanatio per primam intentionem) can be distinguished. Primary wound healing usually occurs in the case of aseptic wounds or fresh injuries. The wound edges have smooth borders and are in close vicinity. Primary wound healing occurs e.g. after a surgical incision in which the edges of the wound are connected by a suture. In general, such wounds will heal within 6 – 8 days.

In contrast, in secondary wound healing the wound cannot be closed by a primary wound closure. The risk of infection is greatly increased by the partially large-scale loss of tissue, or an infection has already occurred. The healing of such wounds often leads to major scarring. Secondary wound healing occurs e.g. in acute wounds with large tissue loss as in dog bites, when primary closure is not possible, or in chronic wounds.

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Effect of obesity on wound healing